Bulldog Health
Bulldog Breeds
Azotemia and glomerular filtration rate in dogs with chronic valvular disease.
BACKGROUND: Little information is available about the prevalence of renal dysfunction in dogs with chronic valvular heart disease (CVD). HYPOTHESIS: Azotemia and a decrease in glomerular filtration rate (GFR) are more severe with increased severity of CVD. ANIMALS: 124 (study No. 1) and 24 (study No. 2) client-owned dogs with CVD. METHODS: A retrospective study (study No. 1) was performed to assess the prevalence of azotemia in the New York Heart Association (NYHA) classes of heart failure in dogs with CVD. A prospective study (study No. 2) was then designed to determine GFR in dogs with different degrees of CVD severity. Complete physical examination, electrocardiography, blood pressure measurement, thoracic radiographs, echocardiography, and plasma and urine analyses were also performed. RESULTS: In study No. 1, 50% of the dogs were azotemic and the percentage of azotemic dogs increased with functional class (up to 70% in NYHA class IV patients). In study No. 2, 8/24 dogs were azotemic. Plasma urea and creatinine were higher in NYHA class III-IV dogs compared with class I-II dogs. The GFR was lower (P < .001) in NYHA class III-IV dogs (1.7 +/- 0.7 mL/min/kg) than in class I to II dogs (3.1 +/- 0.8 mL/min/kg). Only 1 dog in class I-II had a GFR below 2 mL/min/kg and only 2/9 class III-IV dogs had a GFR above 2 mL/min/kg. CONCLUSION AND CLINICAL RELEVANCE: Azotemia and renal impairment increase with the severity of congestive heart failure and are frequent findings in dogs with CVD. It remains to be shown if deterioration of renal function is a direct result of progression of the heart disease
Unité de Cardiologie d'Alfort and INSERM U660, National Veterinary School, 7 Avenue du Général de Gaulle, F94704 Maisons-Alfort Cedex, France.
Nicolle AP, Chetboul V, Allerheiligen T, Pouchelon JL, Gouni V, Tessier-Vetzel D, Sampedrano CC, Lefebvre HP.
The Original Bulldog Club ->> The Bulldog Club of Milan ->>To promote and encourage the Breeding of Pure Bulldogs in all of the World, but more especially In the provinces of England, to Ireland, and in Scotland, in Italy, in Lombardy and in Milan.
Honorary President, Ever and Forever, Mrs. D.N. and Mr. Les Thorpe. Bulldog Club, creato per celebrare la incredibile nascita proprio a Milano, per merito esclusivo di Tuffnuts Bulldogs, in collaborazione con il The Bulldog International Research Center e con Ocobo Show Bulldogs, di quelli che, secondo i più profondi studi mondialmente dimostrabili, risulterebbero essere i più diretti discendenti e, quindi, i legittimi eredi di Rosa, il capostipite della Razza Bulldog, con genealogia integralmente inglese, Lincolnshire, Tuffnuts Ocobo. Il Club si è formato, infatti, nel Dicembre 2004 alla nascita di Tuffnuts Snow Angel Tuffnuts, dedicata al Maggiore L.A. Jackson ed a Dr. Les Cotton, il secondo Original Pure Breed Bulldog, nato a Milano ed in Italia dopo Tully, nato nel 2000, sempre nell ' Allevamento Tuffnuts Snow Angel. Per supportare la razza e tutti coloro che possiedono un Bulldog Inglese. Cucciolate disponibli, affidamento bulldogs, problemi di salute, riproduttori disponibili, etc..Il primo Club che si pone l'obiettivo di selezionare ed allevare anche il Bulldog Originale di Razza Pura, come era fino all' inizio del 20° secolo, con una genealogia completamente inglese, discendente dai più famosi Campioni della Storia.
