Bulldog Health
Bulldog Breeds
A prospective genetic evaluation of familial dilated cardiomyopathy in the Doberman pinscher.
BACKGROUND: The Doberman Pinscher is one of the most common breeds of dogs to develop dilated cardiomyopathy (DCM), a primary heart muscle disorder characterized by myocardial dysfunction, cardiac arrhythmias, and congestive heart failure. In the Doberman Pinscher, the disease is typically adult onset, and a familial etiology has been suggested. HYPOTHESIS: DCM in the Doberman Pinscher, is a familial disease linked to a specific genetic marker. ANIMALS: The study comprised an extended family of Doberman Pinschers with a history of DCM. METHODS: Participating dogs were prospectively evaluated over an 8-year period. Phenotype of participating dogs was determined by annual echocardiography and ambulatory electrocardiography, and the pedigree was evaluated to determine a specific mode of inheritance. Three hundred seventy-two microsatellite markers were selected and genotyped to cover the 38 autosomal chromosomes. Phenotyping, genotyping, and pedigree information was entered into a database, and parametric, 2-point analysis was performed. Markers were considered to be linked to the development of DCM if the logarithm of odds LOD score was >/= 3.0. RESULTS: An autosomal dominant mode of inheritance was defined by the appearance of the disease in multiple generations, equal gender representation (P = .973) and male-to-male transmission. A maximum LOD score of 1.31 was obtained for I marker on chromosome 20, a score not high enough to be associated with DCM. CONCLUSION: DCM in the Doberman Pinscher is a familial disease inherited as an autosomal dominant trait. The causative gene(s) responsible for this condition remain unresolved. Association studies by means of array technology may provide new insights into gene identification.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA. Meurs@vetmed.wsu.edu
Meurs KM, Fox PR, Norgard M, Spier AW, Lamb A, Koplitz SL, Baumwart RD.
The Original Bulldog Club ->> The Bulldog Club of Milan ->>To promote and encourage the Breeding of Pure Bulldogs in all of the World, but more especially In the provinces of England, to Ireland, and in Scotland, in Italy, in Lombardy and in Milan.
Honorary President, Ever and Forever, Mrs. D.N. and Mr. Les Thorpe. Bulldog Club, creato per celebrare la incredibile nascita proprio a Milano, per merito esclusivo di Tuffnuts Bulldogs, in collaborazione con il The Bulldog International Research Center e con Ocobo Show Bulldogs, di quelli che, secondo i più profondi studi mondialmente dimostrabili, risulterebbero essere i più diretti discendenti e, quindi, i legittimi eredi di Rosa, il capostipite della Razza Bulldog, con genealogia integralmente inglese, Lincolnshire, Tuffnuts Ocobo. Il Club si è formato, infatti, nel Dicembre 2004 alla nascita di Tuffnuts Snow Angel Tuffnuts, dedicata al Maggiore L.A. Jackson ed a Dr. Les Cotton, il secondo Original Pure Breed Bulldog, nato a Milano ed in Italia dopo Tully, nato nel 2000, sempre nell ' Allevamento Tuffnuts Snow Angel. Per supportare la razza e tutti coloro che possiedono un Bulldog Inglese. Cucciolate disponibli, affidamento bulldogs, problemi di salute, riproduttori disponibili, etc..Il primo Club che si pone l'obiettivo di selezionare ed allevare anche il Bulldog Originale di Razza Pura, come era fino all' inizio del 20° secolo, con una genealogia completamente inglese, discendente dai più famosi Campioni della Storia.
